Kambo contains a variety of compounds and peptides, and some of them are still a mystery to science. But the ones that scientists have looked at closely seem to have special effects that are tied to the Kambo experience and how it affects people who use it.  What are Peptides? Peptides are like shorter cousins of proteins, made up of amino acids. They stick to cell surfaces and act like messengers, telling the cells to do things like release hormones or change their behavior, affecting everything from your mood and thoughts to muscle movements and digestion.  Phyllomedusin A peptide that has a strong impact on your digestive system. It makes your intestines, bowels, salivary glands, and tear ducts go into action, helping to clean out your digestive system. It's also part of what makes you purge during your Kambo process, and also increases heart rate, heat flushing, and inflammation at location of burns.  Phyllokinin It does some similar things like Phyllomedusin. It's good at opening up blood vessels and making your gut muscles contract. Plus, it helps lower blood pressure and increase blood vessel permeability. Some folks think it might also help other Kambo peptides get into the brain faster, but there's no scientific proof of that yet.  Phyllocaerulein  Found in the highest concentration, Phyllocaerulein is a key player in Kambo's main effects. It significantly impacts the smooth muscles in the gut, making them work harder, while also influencing bile flow and the release of pancreatic and gastric juices. Additionally, it contributes to pain relief in the central nervous system.  Sauvagine It leads to a drop in blood pressure by widening the mesenteric vascular area ( Pancreas) and triggers strong tachycardia. In the central nervous system, it appears to activate the pituitary-adrenal axis, elevating levels of corticosterone, catecholamines (like adrenaline), and plasma glucose. Phyllolitorins Small bioactive peptides that stimulate gastric acid, pancreatic secretion, and smooth muscle contraction. In a study by Caitlin Thompson and Martin L. Williams, it was noted that Litorin can cause a short-term decrease in rats' body temperature by 0.9 °C, which might contribute to shivering and appetite suppression during the later stages of the Kambo experience.   Deltorpin and Dermorphin  It relieves pain and induces a sense of calm by interacting with opioid receptors, potentially aiding individuals with opiate dependence. Dermorphin, like Deltorphins, operates on opioid receptors to reduce pain and regulate mood, providing support for those dealing with opiate dependence.  Dermaseptin  Including Adenoregulin, are part of a family of antimicrobial peptides that help defend the frogs' skin against microbial invaders. In laboratory studies, Adenoregulin has demonstrated the ability to not only inhibit various forms of cancer but also promote the healthy growth of blood vessels.Dermaseptin is also an antiviral for herpes simplex virus.  Antibacterial and AntiviralProperties A lot of the peptides in Kambo are like bodyguards that protect the frog's skin from nasty fungi and germs. Scientists are also looking at these peptides to fight tough, drug-resistant bacteria and viruses, especially in people with weak immune systems, whether from health issues or immunodeficiency disorders.  Learn More Scientific research has identified the peptides Dermorphin and Deltorphin in kambo as potent opioid peptides. Opioids are painkillers and opioid peptides bind to receptors on human cells which trigger a pain masking response. Dermorphin is amazingly 30-40 times stronger than morphine.